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Effect of Zinc Supplementation on Red Blood Cell Osmotic Fragility in hemodialysis Patients

1 Associate Professor, Section of Nephrology, Department of Internal Medicine and Urology Nephrology Research Centre,
2 Student of Medicine,
3 Professor, Section of hematology, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran,
4 Registrar, Department of Transplant Surgery, Renal Transplant Unit, St George’s Hospital, London, United Kingdom,
5 Pediatrician, Department of Public Health, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
*Corresponding Author: M Sharifian , Department of Internal Medicine ,Nemazee Hospital, Shiraz, Iran, Tel.: +98-9177133608, E-mail: [email protected].
Shiraz E-Medical Journal. 2009 October; 10(4): 186-9.
Article Type: Research Article; Received: Jun 24, 2009; Accepted: Aug 28, 2009; epub: Oct 1, 2009; ppub: Oct 2009


Introduction:: Zinc deficiency may aggravate the effect of oxidative stress on RBC (Red Blood
Cell) of chronic uremia. In this study, there is an attempt to show the relationship between
the plasma zinc level and RBC osmotic fragility in hemodialysis patients.

Patients and Methods:: Thirty five patients with low level of serum zinc (serum zinc level<70)
participated in the trial. RBC osmotic fragility, Hb (hemoglobin) and BUN (blood urea nitrogen)
were checked. The patients received zinc supplement (zinc sulfate) (250 mg/day).
Plasma level of zinc, Hb, BUN and osmotic fragility rechecked after 6 weeks.

Results:: The mean serum zinc concentration among the participants increased and it was
statistically significant (p<0.05). Erythrocytes at day 0 (59+/_ 3.5) were significantly (P <
0.05) more fragile in hypotonie saline than those at day 43(38+/_ 2.9), (at NaCl 40%). No
significant changes were noted in the level of Hb

Discussion:: In this trial, oral zinc supplementation caused a significant rises in the plasma
zinc level after 6 weeks. Although Hb concentration was not changed during the trial the level
of osmotic fragility in red cells reduced significantly.

Keywords: Osmotic