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Effect of Opium Addiction on Perioperative Needs to Inotropic Agents in Coronary Artery Bypass Surgery: a Case-Control Study

* Associate Professor, Section of Cardiac Anesthesia, Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran
** Assistant Professor, Section of Cardiac Anesthesia, Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran
+Corresponding Author: S Khademi, #28-Sarrafi Alley, Shahid Motahari Boulevard, Shiraz, Iran, Tel.: +98(917) 7101-539, Fax: +98(711) 2337-663, E-mail: [email protected].
Shiraz E-Medical Journal. 13(1): 5-12.
Article Type: Research Article; Received: Oct 21, 2011; Accepted: Oct 22, 2011; epub: Jan 1, 2012;


Methods and Material: 62 male patients up to 75 yrs old scheduled for elective on-pump CABG with ejection fraction>40% were assigned to two groups according to DSM- IV, TR: Opium dependent and nondependent patients. Anesthesia induced and maintained similarly in all patients. During the perioperative period blood pressure(BP),heart rate (HR, central venous pressure (CVP),cardiac output (co),systemic vascular resistance (SVR) ,type and length of inotropes used and the frequency of intra aortic balloon pump (IABP) insertion were monitored and recorded . Paired sample t-test, Independent sample t- test and Chi-Square test were used to compare variables among two groups.

Result: Demographic data showed no significant difference in age, body mass index (BMI), preoperative hemoglobin, ejection fraction (EF) and number of grafts in two groups. Also there was no significant difference regarding the incidence of cardiovascular risk factors and mean blood pressure(MBP). The findings indicated no significant difference in the fre-quency of inotrope usage[23(74.1%) vs. 25(80.6%); p=0.381] and frequency of IABP insertion [2(6.4%) vs. 3(9.6%); p=0.187] between two groups . But the lenght of the need to inotropes in opium dependent patients was significantly lower in comparison with nonde-pendent patients (26.8± 9.9 vs. 36.1± 17.45; p=0.042).

Objective: to compare the need to inotropic agents in opium dependent (OD) and non de-pendent (NOD) patients during the perioperative period in patients undergoing coronary artery bypass graft (CABG) surgery.

Conclusion: Although the length of the need to inotropic support in non opium dependent was longer as compared to opium dependent patients, frequency of inotrope need and specific inotrope usage and also frequency of IABP insertion was not different between the two groups.

Keywords: Opium dependent, non opium dependent, coronary artery bypass graft, Inotrope